Glaucoma Patients Have a Lower Abundance of Butyrate-Producing Taxa in the Gut.

ABSTRACT:

Purpose

Glaucoma is an eye disease that is the most common cause of irreversible blindness worldwide. It has been suggested that gut microbiota can produce reactive oxygen species and pro-inflammatory cytokines that may travel from the gastric mucosa to distal sites, for example, the optic nerve head or trabecular meshwork. There is evidence for a gut-eye axis, as microbial dysbiosis has been associated with retinal diseases. We investigated the microbial composition in patients with glaucoma and healthy controls. Moreover, we analyzed the association of the gut microbiome with intraocular pressure (IOP; risk factor of glaucoma) and vertical cup-to-disc ratio (VCDR; quantifying glaucoma severity).

Methods

The discovery analyses included participants of the Rotterdam Study an

SUBMITTER: Vergroesen JE 

PROVIDER: S-EPMC10851784 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature