Comprehensive assessment of sleep duration, insomnia, and brain structure within the UK Biobank cohort.

ABSTRACT:

Study objectives

To assess for associations between sleeping more than or less than recommended by the National Sleep Foundation (NSF), and self-reported insomnia, with brain structure.

Methods

Data from the UK Biobank cohort were analyzed (N between 9K and 32K, dependent on availability, aged 44 to 82 years). Sleep measures included self-reported adherence to NSF guidelines on sleep duration (sleeping between 7 and 9 hours per night), and self-reported difficulty falling or staying asleep (insomnia). Brain structural measures included global and regional cortical or subcortical morphometry (thickness, surface area, volume), global and tract-related white matter microstructure, brain age gap (difference between chronological age and age estimated from brain scan), and total

SUBMITTER: Stolicyn A 

PROVIDER: S-EPMC10851840 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature