Genetics of sleep medication purchases suggests causality from sleep problems to psychiatric traits.

ABSTRACT:

Study objectives

Over 10% of the population in Europe and in the United States use sleep medication to manage sleep problems. Our objective was to elucidate genetic risk factors and clinical correlates that contribute to sleep medication purchase and estimate the comorbid impact of sleep problems.

Methods

We performed epidemiological analysis for psychiatric diagnoses, and genetic association studies of sleep medication purchase in 797 714 individuals from FinnGen Release 7 (N = 311 892) and from the UK Biobank (N = 485 822). Post-association analyses included genetic correlation, co-localization, Mendelian randomization (MR), and polygenic risk estimation.

Results

In a GWAS we identified 27 genetic loci significantly associated with sleep medication, located in genes

SUBMITTER: Broberg M 

PROVIDER: S-EPMC10851853 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature