Linking brain structure, cognition, and sleep: insights from clinical data.

ABSTRACT:

Study objectives

To use relatively noisy routinely collected clinical data (brain magnetic resonance imaging (MRI) data, clinical polysomnography (PSG) recordings, and neuropsychological testing), to investigate hypothesis-driven and data-driven relationships between brain physiology, structure, and cognition.

Methods

We analyzed data from patients with clinical PSG, brain MRI, and neuropsychological evaluations. SynthSeg, a neural network-based tool, provided high-quality segmentations despite noise. A priori hypotheses explored associations between brain function (measured by PSG) and brain structure (measured by MRI). Associations with cognitive scores and dementia status were studied. An exploratory data-driven approach investigated age-structure-physiology-cognition lin

SUBMITTER: Wei R 

PROVIDER: S-EPMC10851868 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature