Neuropathologic Changes of Alzheimer's Disease and Related Dementias: Relevance to Future Prevention.

ABSTRACT:

Background

Decedents with late-life dementia are often found at autopsy to have vascular pathology, cortical Lewy bodies, hippocampal sclerosis, and/or TDP-43 encephalopathy alone or with concurrent Alzheimer's disease (AD) lesions. Nonetheless, it is commonly believed that AD neuropathologic changes (NC) are the dominant or exclusive drivers of late-life dementia.

Objective

Assess associations of end-of-life cognitive impairment with any one or any combination of five distinct NC. Assess impairment prevalence among subjects having natural resistance to each type of NC.

Methods

Brains from 1,040 autopsied participants of the Honolulu-Asia Study, the Nun Study, and the 90 + Study were examined for NC of AD, Lewy body dementia, microvascular brain injury, hippocampal sc

SUBMITTER: White LR 

PROVIDER: S-EPMC10851925 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature