Sputum microbiome α-diversity is a key feature of the COPD frequent exacerbator phenotype.

ABSTRACT:

Background

The lung microbiome is an inflammatory stimulus whose role in COPD pathogenesis is incompletely understood. We hypothesised that the frequent exacerbator phenotype is associated with decreased α-diversity and increased lung inflammation. Our objective was to assess correlations between the frequent exacerbator phenotype, the microbiome and inflammation longitudinally during exacerbation-free periods.

Methods

We conducted a case-control longitudinal observational study of the frequent exacerbator phenotype and characteristics of the airway microbiome. 81 subjects (41 frequent and 40 infrequent exacerbators) provided nasal, oral and sputum microbiome samples at two visits over 2-4 months. Exacerbation phenotype, relevant clinical factors and sputum cytokine values w

SUBMITTER: Pragman AA 

PROVIDER: S-EPMC10851948 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature