Angiotensin II induces endothelial dysfunction and vascular remodeling by downregulating TRPV4 channels.

ABSTRACT: Angiotensin II (Ang II) is a potent vasoconstrictor of vascular smooth muscle cells (VSMC) and is implicated in hypertension, but it's role in the regulation of endothelial function is not well known. We and others have previously shown that mechanically activated ion channel, Transient Receptor Potential Vanilloid 4 (TRPV4) mediates flow- and/or receptor-dependent vasodilation via nitric oxide (NO) production in endothelial cells. Ang II was demonstrated to crosstalk with TRPV4 via angiotensin 1 receptor (AT1R) and β-arrestin signaling in epithelial and immortalized cells, however, the role of this crosstalk in endothelial cell function is not fully explored. Ang II treatment significantly downregulated TRPV4 protein expression and TRPV4-mediated Ca²⁺ influx in human EC without

SUBMITTER: Kondapalli NB 

PROVIDER: S-EPMC10852140 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature