Small dense low density lipoprotein predominance in patients with type 2 diabetes mellitus using Mendelian randomization.

ABSTRACT:

Background

Patients with T2DM often suffer from CVD-related complications, significantly impacting morbidity and mortality rates. The upsurge in CVD prevalence among them is partly linked to sd LDL particles. Understanding the mechanisms behind elevated sd LDL levels is critical for preventing and managing cardiovascular complications in diabetes.

Methods

MR was employed to identify instrumental variables and establish causality, exploring underlying mechanisms.

Results

Notably, T2DM itself, insulin resistance, and fasting glucose seemingly do not directly impact sd LDL levels. Instead, the presence of T2DM or insulin resistance, leading to reduced HDL cholesterol or elevated TG levels, directly contributes to subsequent sd LDL increases, indicating a comprehensive me

SUBMITTER: Zhang F 

PROVIDER: S-EPMC10852223 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature