What is your count? An observational study of lymph node counting in 2,028 colorectal cancer resections.

ABSTRACT:

Background

Lymph node status and lymph node count (LNC) are predictors of colorectal cancer outcome. Under-sampling of lymph nodes may lead to clinically relevant stage migration.

Methods

Colorectal cancer (CRC) cases with a synoptic report, accessioned 2012-2020 at a regional laboratory, were extracted and retrospectively studied. LNC, positive lymph node count (PLNC), tumour deposits present (TDpos), and 'y' (staging) prefix (YS) were retrieved and tabulated by pathologist using custom software. Statistical analyses were done with R.

Data and results

The cohort had 2,543 CRC resections. Seventeen pathologists interpreted >50 cases (range: 56-356) each and collectively saw 2,074. After cases with unavailable data were purged, 2,028 cases remained with 43,996 lymph no

SUBMITTER: Srivastava S 

PROVIDER: S-EPMC10852306 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature