Machine perfusion of the liver and in vivo animal models: A systematic review of the preclinical research landscape.

ABSTRACT: Machine perfusion (MP) is often referred to as one of the most promising advancements in liver transplantation research of the last few decades, with various techniques and modalities being evaluated in preclinical studies using animal models. However, low scientific rigor and subpar reporting standards lead to limited reproducibility and translational potential, hindering progress. This pre-registered systematic review (PROSPERO: CRD42021234667) aimed to provide a thematic overview of the preclinical research landscape on MP in liver transplantation using in vivo transplantation models and to explore methodological and reporting standards, using the ARRIVE (Animal Research: Reporting of In Vivo Experiments) score. In total 56 articles were included. Studies were evenly distributed across

SUBMITTER: Liu W 

PROVIDER: S-EPMC10852327 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature