Mechanistic role of alpha oscillations in a computational model of working memory.

ABSTRACT: Brain oscillations are believed to be involved in the different operations necessary to manipulate information during working memory tasks. We propose a mechanistic role for the observed inhibition effect of the alpha rhythm based on its interference with the theta rhythm. Using the Lisman-Idiart model for multi-item working memory, we show that the interaction between these two oscillations is capable of creating a long lasting destructive interference that prevents the cyclic reactivation of neuronal ensembles and, as a consequence, memory maintenance. Additionally, to ensure robustness we propose a modular version of the model and implement oscillations as traveling waves. Using this model, we show that the interactions between theta and gamma determine the allocation of multiple memori

SUBMITTER: Soroka G 

PROVIDER: S-EPMC10852337 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature