Clinical and molecular characteristics of early-onset vs average-onset esophagogastric cancer.

ABSTRACT:

Background

The rate of esophagogastric cancer is rising among individuals under 50 years of age. It remains unknown whether early-onset esophagogastric cancer represents a unique entity. This study investigated the clinical and molecular characteristics of early-onset and average-onset esophagogastric cancer .

Methods

We reviewed the Memorial Sloan Kettering Cancer Center gastric, esophageal, and gastroesophageal junction cancer database. Associations between baseline characteristics and tumor and germline molecular alterations were compared between those with early-onset and average-onset esophagogastric cancer using Fisher exact tests and the Benjamini-Hochberg method for multiple-hypothesis correction.

Results

We included 1123 patients with early-onset esophagogast

SUBMITTER: Lumish MA 

PROVIDER: S-EPMC10852615 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature