Evolving therapies, neurocognitive outcomes, and functional independence in adult survivors of childhood glioma.

ABSTRACT:

Background

Treatment of childhood glioma has evolved to reduce radiotherapy exposure with the goal of limiting late toxicity. However, the associations between treatment changes and neurocognition, and the contribution of neurocognition and chronic health conditions to attainment of adult independence, remain unknown.

Methods

Adult survivors of childhood glioma diagnosed in 1970-1999 in the Childhood Cancer Survivor Study (n = 1284; median [minimum-maximum] 30 [18-51] years of age at assessment; 22 [15-34] years from diagnosis) self-reported neurocognitive impairment and chronic health conditions. Multivariable models evaluated associations between changes in treatment exposures (surgery only, chemotherapy [with or without surgery], cranial radiation [with or without chemoth

SUBMITTER: Papini C 

PROVIDER: S-EPMC10852618 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature