The Relationship of Alcohol Consumption and Drinking Pattern to the Risk of Glomerular Hyperfiltration in Middle-aged Japanese Men: The Kansai Healthcare Study.

ABSTRACT:

Background

Glomerular hyperfiltration has been reported to be associated with adverse renal outcomes in the general population. It is not known whether drinking pattern is associated with the risk of glomerular hyperfiltration in healthy individuals.

Methods

We prospectively followed middle-aged 8,640 Japanese men with normal renal function, no proteinuria, no diabetes, and no use of antihypertensive medications at entry. Data on alcohol consumption were gathered by questionnaire. Glomerular hyperfiltration was defined as estimated glomerular filtration rate (eGFR) ≥117 mL/min/1.73 m², which was the upper 2.5th percentile value of eGFR in the entire cohort.

Results

During 46,186 person-years of follow-up, 330 men developed glomerular hyperfiltration. In a m

SUBMITTER: Shibata M 

PROVIDER: S-EPMC10853046 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature