The impact of leucine supplementation on body composition and glucose tolerance following energy restriction: an 8-week RCT in adults at risk of the metabolic syndrome.

ABSTRACT:

Background

L-Leucine (Leu) supplementation may benefit fat-free mass (FFM) per se and glucose metabolism.

Objectives

To determine whether Leu supplementation during energy restriction blunted the loss of FFM, enhanced the loss of fat mass (FM) and improved glucose tolerance.

Design

Thirty-seven adults, aged 20-65 years, with increased waist circumference and at least one other metabolic syndrome (MetS) component, were selected. We employed a two-arm parallel, double blind, randomized control trial (RCT) design. Participants were randomly assigned to an intervention group (leucine - 3 g/d) or placebo (lactose - 2.67 g/d), while following an individualised energy restricted diet for an 8-week period. Detailed body composition (DEXA), oral glucose tolerance test (OGTT),

SUBMITTER: Pathak K 

PROVIDER: S-EPMC10853066 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature