Direct Detection of Viral Infections from Swab Samples by Probe-Gated Silica Nanoparticle-Based Lateral Flow Assay.

ABSTRACT: Point-of-care diagnosis is crucial to control the spreading of viral infections. Here, universal-modifiable probe-gated silica nanoparticles (SNPs) based lateral flow assay (LFA) is developed in the interest of the rapid and early detection of viral infections. The most superior advantage of the rapid assay is its utility in detecting various sides of the virus directly from the human swab samples and its adaptability to detect various types of viruses. For this purpose, a high concentration of fluorescein and rhodamine B as a reporting material was loaded into SNPs with excellent loading capacity and measured using standard curve, 4.19 μmol ⋅ g^-1 and 1.23 μmol ⋅ g^-1 , respectively. As a model organism, severe acute respiratory syndrome coronavirus-2 (CoV-2) infection

SUBMITTER: Durdabak DB 

PROVIDER: S-EPMC10853071 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature