Digital breast tomosynthesis in mammographic screening: false negative cancer cases in the To-Be 1 trial.

ABSTRACT:

Objectives

The randomized controlled trial comparing digital breast tomosynthesis and synthetic 2D mammograms (DBT + SM) versus digital mammography (DM) (the To-Be 1 trial), 2016-2017, did not result in higher cancer detection for DBT + SM. We aimed to determine if negative cases prior to interval and consecutive screen-detected cancers from DBT + SM were due to interpretive error.

Methods

Five external breast radiologists performed the individual blinded review of 239 screening examinations (90 true negative, 39 false positive, 19 prior to interval cancer, and 91 prior to consecutive screen-detected cancer) and the informed consensus review of examinations prior to interval and screen-detected cancers (n = 110). The reviewers marked suspicious findings with a score of 1-5 (

SUBMITTER: Moshina N 

PROVIDER: S-EPMC10853101 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature