Polymeric DNase-I nanozymes targeting neutrophil extracellular traps for the treatment of bowel inflammation.

ABSTRACT: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a family of chronic disorders along the gastrointestinal tract. Because of its idiopathic nature, IBD does not have a fundamental cure; current available therapies for IBD are limited to prolonged doses of immunomodulatory agents. While these treatments may reduce inflammation, limited therapeutic efficacy, inconsistency across patients, and adverse side effects from aggressive medications remain as major drawbacks. Recently, excessive production and accumulation of neutrophil extracellular traps (NETs) also known as NETosis have been identified to exacerbate inflammatory responses and induce further tissue damage in IBD. Such discovery invited many researchers to investigate NETs as a potential therapeu

SUBMITTER: Wang CJ 

PROVIDER: S-EPMC10853102 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature