Constructing models for Crohn's disease diagnosis and prediction of infliximab non-response based on angiogenesis-related genes.

ABSTRACT:

Background

Angiogenesis response plays a crucial role in the occurrence and development of Crohn's disease (CD) and may involve the mechanism of infliximab non-response. However, the role of angiogenesis-related genes in Crohn's disease has not been comprehensively studied. This study aimed to explore the expression profiles of angiogenesis-related genes in CD patients and construct models for disease diagnosis and prediction of infliximab non-response.

Methods

CD-related microarray datasets were collected from the GEO database. Unsupervised consensus clustering analysis was performed based on differentially expressed angiogenesis-related genes to divide CD samples into two distinct clusters. Weighted gene co-expression network analysis (WGCNA) was conducted on the clusters

SUBMITTER: Zheng C 

PROVIDER: S-EPMC10853379 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature