Integrated analysis reveals crosstalk between pyroptosis and immune regulation in renal fibrosis.

ABSTRACT:

Purpose

The pathogenesis of renal fibrosis (RF) involves intricate interactions between profibrotic processes and immune responses. This study aimed to explore the potential involvement of the pyroptosis signaling pathway in immune microenvironment regulation within the context of RF. Through comprehensive bioinformatics analysis and experimental validation, we investigated the influence of pyroptosis on the immune landscape in RF.

Methods

We obtained RNA-seq datasets from Gene Expression Omnibus (GEO) databases and identified Pyroptosis-Associated Regulators (PARs) through literature reviews. Systematic evaluation of alterations in 27 PARs was performed in RF and normal kidney samples, followed by relevant functional analyses. Unsupervised cluster analysis revealed distinct

SUBMITTER: Bai F 

PROVIDER: S-EPMC10853448 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature