Regional spinal cord volumes and pain profiles in AQP4-IgG + NMOSD and MOGAD.

ABSTRACT:

Objective

Aquaporin-4-antibody-seropositive (AQP4-IgG+) Neuromyelitis Optica Spectrum Disorder (NMOSD) and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder (MOGAD) are relapsing neuroinflammatory diseases, frequently leading to chronic pain. In both diseases, the spinal cord (SC) is often affected by myelitis attacks. We hypothesized that regional SC volumes differ between AQP4-IgG + NMOSD and MOGAD and that pain intensity is associated with lower SC volumes. To evaluate changes in the SC white matter (WM), gray matter (GM), and pain intensity in patients with recent relapses (myelitis or optic neuritis), we further profiled phenotypes in a case series with longitudinal imaging and clinical data.

Methods

Cross-sectional data from 36 participants were analyzed

SUBMITTER: Asseyer S 

PROVIDER: S-EPMC10853470 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature