The Aspergillus fumigatus maiA gene contributes to cell wall homeostasis and fungal virulence.

ABSTRACT: In this study, two distinct in vitro infection models of Aspergillus fumigatus, using murine macrophages (RAW264.7) and human lung epithelial cells (A549), were employed to identify the genes important for fungal adaptation during infection. Transcriptomic analyses of co-incubated A. fumigatus uncovered 140 fungal genes up-regulated in common between both models that, when compared with a previously published in vivo transcriptomic study, allowed the identification of 13 genes consistently up-regulated in all three infection conditions. Among them, the maiA gene, responsible for a critical step in the L-phenylalanine degradation pathway, was identified. Disruption of maiA resulted in a mutant strain unable to complete the Phe degradation pathway, l

SUBMITTER: Guruceaga X 

PROVIDER: S-EPMC10853476 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature