Cervicovaginal Microbial-Immune State and Group B Streptococcus Colonization in Pregnancy.

ABSTRACT:

Objective

Maternal colonization with Group B Streptococcus (GBS) is a significant risk factor for serious neonatal morbidity. There are limited data on how the cervicovaginal (CV) microbiota and host immune factor β-defensin-2 might influence GBS colonization in pregnant individuals. This study sought to determine if the CV microbiota is associated with GBS colonization in pregnant individuals, and if β-defensin-2 modifies this relationship.

Study design

This was a secondary analysis of a prospective cohort study of pregnant individuals with singleton pregnancies who had CV microbiota specimens analyzed at 16 to 20, 20 to 24, and 24 to 28 weeks' gestation, along with a third trimester GBS rectovaginal (RV) culture (n = 492). Microbiota data were analyzed with 1

SUBMITTER: McCoy JA 

PROVIDER: S-EPMC10853487 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature