Dataset Information

Hybrid AI-enhanced lightning flash prediction in the medium-range forecast horizon.

ABSTRACT: Traditional fully-deterministic algorithms, which rely on physical equations and mathematical models, are the backbone of many scientific disciplines for decades. These algorithms are based on well-established principles and laws of physics, enabling a systematic and predictable approach to problem-solving. On the other hand, AI-based strategies emerge as a powerful tool for handling vast amounts of data and extracting patterns and relationships that might be challenging to identify through traditional algorithms. Here, we bridge these two realms by using AI to find an optimal mapping of meteorological features predicted two days ahead by the state-of-the-art numerical weather prediction model by the European Centre for Medium-range Weather Forecasts (ECMWF) into lightning flash occurrence. The prediction capability of the resulting AI-enhanced algorithm turns out to be significantly higher than that of the fully-deterministic algorithm employed in the ECMWF model. A remarkable Recall peak of about 95% within the 0-24 h forecast interval is obtained. This performance surpasses the 85% achieved by the ECMWF model at the same Precision of the AI algorithm.

SUBMITTER: Cavaiola M

PROVIDER: S-EPMC10853497 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Hybrid AI-enhanced lightning flash prediction in the medium-range forecast horizon.

Cavaiola Mattia M Cassola Federico F Sacchetti Davide D Ferrari Francesco F Mazzino Andrea A

Nature communications 20240208 1

Traditional fully-deterministic algorithms, which rely on physical equations and mathematical models, are the backbone of many scientific disciplines for decades. These algorithms are based on well-established principles and laws of physics, enabling a systematic and predictable approach to problem-solving. On the other hand, AI-based strategies emerge as a powerful tool for handling vast amounts of data and extracting patterns and relationships that might be challenging to identify through trad ...[more]

PMID: 38331837

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Project description:A fully automated and accurate assay of rare cell phenotypes in densely-packed fluorescently-labeled liquid biopsy images remains elusive. Methods: Employing a hybrid artificial intelligence (AI) paradigm that combines traditional rule-based morphological manipulations with modern statistical machine learning, we deployed a next generation software, ALICE (Automated Liquid Biopsy Cell Enumerator) to identify and enumerate minute amounts of tumor cell phenotypes bestrewed in massive populations of leukocytes. As a code designed for futurity, ALICE is armed with internet of things (IOT) connectivity to promote pedagogy and continuing education and also, an advanced cybersecurity system to safeguard against digital attacks from malicious data tampering. Results: By combining robust principal component analysis, random forest classifier and cubic support vector machine, ALICE was able to detect synthetic, anomalous and tampered input images with an average recall and precision of 0.840 and 0.752, respectively. In terms of phenotyping enumeration, ALICE was able to enumerate various circulating tumor cell (CTC) phenotypes with a reliability ranging from 0.725 (substantial agreement) to 0.961 (almost perfect) as compared to human analysts. Further, two subpopulations of circulating hybrid cells (CHCs) were serendipitously discovered and labeled as CHC-1 (DAPI+/CD45+/E-cadherin+/vimentin-) and CHC-2 (DAPI+ /CD45+/E-cadherin+/vimentin+) in the peripheral blood of pancreatic cancer patients. CHC-1 was found to correlate with nodal staging and was able to classify lymph node metastasis with a sensitivity of 0.615 (95% CI: 0.374-0.898) and specificity of 1.000 (95% CI: 1.000-1.000). Conclusion: This study presented a machine-learning-augmented rule-based hybrid AI algorithm with enhanced cybersecurity and connectivity for the automatic and flexibly-adapting enumeration of cellular liquid biopsies. ALICE has the potential to be used in a clinical setting for an accurate and reliable enumeration of CTC phenotypes.

Dataset Information

Hybrid AI-enhanced lightning flash prediction in the medium-range forecast horizon.

Publications

Hybrid AI-enhanced lightning flash prediction in the medium-range forecast horizon.

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