Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice.

ABSTRACT: Surgical removal of the thyroid gland (TG) for treating thyroid disorders leaves the patients on lifelong hormone replacement that partially compensates the physiological needs, but regenerating TG is challenging. Here, an approach is reported to regenerate TG within the spleen for fully restoring the thyroid's functions in mice, by transplanting thyroid tissue blocks to the spleen. Within 48 h, the transplanted tissue efficiently revascularizes, forming thyroid follicles similar to the native gland after 4 weeks. Structurally, the ectopically generated thyroid integrates with the surrounding splenic tissue while maintaining its integrity, separate from the lymphatic tissue. Functionally, it fully restores the native functions of the TG in hormone regulation in response to physiological st

SUBMITTER: Tian XJ 

PROVIDER: S-EPMC10853707 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature