An Erythrocyte-Templated Iron Single-Atom Nanozyme for Wound Healing.

ABSTRACT: Iron single-atom nanozymes represent a promising artificial enzyme with superior activity owing to uniform active sites that can precisely mimic active center of nature enzymes. However, current synthetic strategies are hard to guarantee each active site at single-atom state. In this work, an erythrocyte-templated strategy by utilizing intrinsic hemin active center of hemoglobin as sing-atom source for nanozyme formation is developed. By combining cell fixation, porous salinization, and high-temperature carbonization, erythrocytes are successfully served as uniform templates to synthesize nanozymes with fully single-atom FeN₄ active sites which derived from hemin of hemoglobin, resulting in an enhanced peroxidase (POD)-like activity. Interestingly, the catalytic activity of eryt

SUBMITTER: Wang X 

PROVIDER: S-EPMC10853745 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature