White matter hyperintensities in bipolar disorder: systematic review and meta-analysis.

ABSTRACT:

Background

White matter hyperintensities are lesions of presumed vascular origin associated with Cerebral small vessel disease. WMH are common findings that and are associated with increased risk of cognitive impairment and dementia. A higher prevalence of WMH has been also reported in patients with bipolar disorder (BD), although the evidence is conflicting.

Objective

To compare the prevalence of WMH in adults with BD, with the prevalence found in healthy controls.

Methods

We searched the Embase, Medline/PubMed, and references cited in articles retrieved on May 20, 2023. We included case-control studies that compared the prevalence of WMH in adult BD patients with the prevalence of WMH in healthy controls, using T2-weighted magnetic resonance imaging. We performed a

SUBMITTER: Silva T 

PROVIDER: S-EPMC10853814 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature