Hippocampal Structures Among Japanese Adolescents Before and After the COVID-19 Pandemic.

ABSTRACT:

Importance

Few studies have used a large-sample, longitudinal, population-based cohort study to examine whether the COVID-19 pandemic as a global major life event is associated with structural plasticity of the adolescent hippocampus.

Objective

To examine whether Japan's first state of emergency (SoE) during the COVID-19 pandemic was associated with alterations in the macrostructures and microstructures of the hippocampus during its development.

Design, setting, and participants

The population-neuroscience Tokyo TEEN Cohort study is a prospective cohort study with 4 consecutive waves in Tokyo, Japan. Due to the SoE, data collection was suspended between March 27, 2020, and July 30, 2020. Analyzed data, comprising 1149 brain structural scans obtained from 479 participa

SUBMITTER: Cai L 

PROVIDER: S-EPMC10853829 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature