Step Serial Sectioning in Head and Neck Squamous Cell Carcinoma of Unknown Primary.

ABSTRACT:

Importance

Patients with suspected head and neck squamous cell carcinoma of unknown primary (HNSCCUP) may undergo tonsillectomy and tongue base mucosectomy (TBM) to help identify clinicoradiologically occult primary disease. It is hypothesized that when these diagnostic specimens are analyzed, conventional histopathological (CH) techniques risk missing small primary tumors that may be hidden in the tissue blocks.

Objective

To establish the outcomes of a step serial sectioning (SSS) histopathological technique vs CH when analyzing diagnostic tissue specimens from TBM and tonsillectomy performed for HNSCCUP.

Design, setting, and participants

The MOSES prospective multicenter noninterventional cohort study was conducted over a 25-month period from November 2019 at second

SUBMITTER: Hardman JC 

PROVIDER: S-EPMC10853833 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature