Gut microbiota regulates hepatic ischemia-reperfusion injury-induced cognitive dysfunction via the HDAC2-ACSS2 axis in mice.

ABSTRACT:

Aims

Hepatic ischemia-reperfusion injury (HIRI) resulting from hepatic inflow occlusion, which is a common procedure in liver surgery is inevitable. Previous research has confirmed that the cognitive dysfunction induced by HIRI is closely related to dysbiosis of the gut microbiota. This research aims to investigate the mechanisms underlying this complication.

Methods

C57BL/6 mice underwent hepatic ischemia experimentally through the occlusion of the left hepatic artery and portal vein. To assess the HDAC2-ACSS2 axis, gut microbiota transplantation. Enzyme-linked immunosorbent assay and LC/MS short-chain fatty acid detection were utilized.

Results

The findings indicated a notable decline in ACSS2 expression in the hippocampus of mice experiencing hepatic ischemia-reper

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10853894 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature