Detection of skin α-synuclein using RT-QuIC as a diagnostic biomarker for Parkinson's disease in the Chinese population.

ABSTRACT:

Background

Several studies have indicated that skin holds promise as a potential sample for detecting pathological α-Syn and serving as a diagnostic biomarker for α-synucleinopathies. Despite reports in Chinese PD patients, comprehensive research on skin α-Syn detection using RT-QuIC is lacking.

Objective

This study aimed to evaluate the diagnostic performance of skin samples using RT-QuIC from PD patients in the Chinese population.

Methods

Patients with sporadic PD and controls were included according to the British PD Association Brain Bank diagnostic criteria. The seeding activity of misfolded α-Syn in these skin samples was detected using the RT-QuIC assay after protein extraction. Biochemical and morphological analyses of RT-QuIC products were conducted by atomic

SUBMITTER: Li J 

PROVIDER: S-EPMC10854029 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature