Intestinal metabolites predict treatment resistance of patients with depression and anxiety.

ABSTRACT:

Background

The impact of the gut microbiota on neuropsychiatric disorders has gained much attention in recent years; however, comprehensive data on the relationship between the gut microbiome and its metabolites and resistance to treatment for depression and anxiety is lacking. Here, we investigated intestinal metabolites in patients with depression and anxiety disorders, and their possible roles in treatment resistance.

Results

We analyzed fecal metabolites and microbiomes in 34 participants with depression and anxiety disorders. Fecal samples were obtained three times for each participant during the treatment. Propensity score matching led us to analyze data from nine treatment responders and nine non-responders, and the results were validated in the residual sample sets.

SUBMITTER: Matsuzaki J 

PROVIDER: S-EPMC10854080 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature