Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy.

ABSTRACT:

Background

Chemotherapy-induced peripheral neuropathy (CIPN) represents a major unmet medical need that currently has no preventive and/or curative treatment. This is, among others, driven by a poor understanding of the contributive role of drug transport across biological barriers to target-site exposure.

Methods

Here, we systematically investigated the transport of 11 small-molecule drugs, both, associated and not with CIPN development, at conventional (dorsal root ganglia, sciatic nerve) and non-conventional (brain, spinal cord, skeletal muscle) CIPN sites. We developed a Combinatory Mapping Approach for CIPN, CMA-CIPN, combining in vivo and in vitro elements.

Results

Using CMA-CIPN, we determined the unbound tissue-to-plasma concentration ratio (K_p,uu)

SUBMITTER: Hu Y 

PROVIDER: S-EPMC10854123 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature