TFRC, associated with hypoxia and immune, is a prognostic factor and potential therapeutic target for bladder cancer.

ABSTRACT:

Background

Bladder cancer is a common malignancy of the urinary system, and the survival rate and recurrence rate of patients with muscular aggressive (MIBC) bladder cancer are not ideal. Hypoxia is a pathological process in which cells acquire special characteristics to adapt to anoxic environment, which can directly affect the proliferation, invasion and immune response of bladder cancer cells. Understanding the exact effects of hypoxia and immune-related genes in BLCA is helpful for early assessment of the prognosis of BLCA. However, the prognostic model of BLCA based on hypoxia and immune-related genes has not been reported.

Purpose

Hypoxia and immune cell have important role in the prognosis of bladder cancer (BLCA). The aim of this study was to investigate whether hypo

SUBMITTER: Tang R 

PROVIDER: S-EPMC10854140 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature