Causal relationships between delirium and Parkinson's disease: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Previous observational studies have suggested a notably elevated prevalence of delirium in individuals diagnosed with Parkinson's disease (PD), thereby implying a potential increased susceptibility to delirium among PD patients. However, it is imperative to acknowledge that observational studies inherently possess limitations, rendering it arduous to establish a definitive causal or reverse causal association between delirium and PD.

Methods

To explore the relationship between delirium and PD, a bidirectional two-sample Mendelian randomization (MR) was conducted using summary statistics obtained from genome-wide association studies. The main analysis was performed using the inverse-variance weighted (IVW) method, with further analyses conducted using MR Egger, wei

SUBMITTER: Bai X 

PROVIDER: S-EPMC10854158 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature