Microbial-derived imidazole propionate links the heart failure-associated microbiome alterations to disease severity.

ABSTRACT:

Background

Interactions between the gut microbiota, diet, and host metabolism contribute to the development of cardiovascular disease, but a firm link between disease-specific gut microbiota alterations and circulating metabolites is lacking.

Methods

We performed shot-gun sequencing on 235 samples from 166 HF patients and 69 healthy control samples. Separate plasma samples from healthy controls (n = 53) were used for the comparison of imidazole propionate (ImP) levels. Taxonomy and functional pathways for shotgun sequencing data was assigned using MetaPhlAn3 and HUMAnN3 pipelines.

Results

Here, we show that heart failure (HF) is associated with a specific compositional and functional shift of the gut microbiota that is linked to circulating levels of the microbial his

SUBMITTER: Raju SC 

PROVIDER: S-EPMC10854170 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature