Competing risk analysis of cardiovascular disease risk in breast cancer patients receiving a radiation boost.

ABSTRACT:

Background

Thoracic radiotherapy may damage the myocardium and arteries, increasing cardiovascular disease (CVD) risk. Women with a high local breast cancer (BC) recurrence risk may receive an additional radiation boost to the tumor bed.

Objective

We aimed to evaluate the CVD risk and specifically ischemic heart disease (IHD) in BC patients treated with a radiation boost, and investigated whether this was modified by age.

Methods

We identified 5260 BC patients receiving radiotherapy between 2005 and 2016 without a history of CVD. Boost data were derived from hospital records and the national cancer registry. Follow-up data on CVD events were obtained from Statistics Netherlands until December 31, 2018. The relation between CVD and boost was evaluated with competing ri

SUBMITTER: Koop Y 

PROVIDER: S-EPMC10854185 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature