Genome-wide DNA N6-methyladenosine in Aeromonas veronii and Helicobacter pylori.

ABSTRACT:

Background

DNA N6-methyladenosine (6mA), as an important epigenetic modification, widely exists in bacterial genomes and participates in the regulation of toxicity, antibiotic resistance, and antioxidant. With the continuous development of sequencing technology, more 6mA sites have been identified in bacterial genomes, but few studies have focused on the distribution characteristics of 6mA at the whole-genome level and its association with gene expression and function.

Results

This study conducted an in-depth analysis of the 6mA in the genomes of two pathogenic bacteria, Aeromonas veronii and Helicobacter pylori. The results showed that the 6mA was widely distributed in both strains. In A. veronii, 6mA sites were enriched at 3' end of protein-coding genes, exhibiting a certa

SUBMITTER: Zhao H 

PROVIDER: S-EPMC10854192 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature