Analysis of differences in intestinal flora associated with different BMI status in colorectal cancer patients.

ABSTRACT:

Background

Overweight is known to be an important risk factor for colorectal cancer (CRC), and the differences in intestinal flora among CRC patients with different BMI status have not been clearly defined. The purpose of this study was to elucidate the differences in the abundance, composition and biological function of intestinal flora in CRC patients with different BMI status.

Method

A total of 170 CRC patients were included and grouped according to the BMI data of CRC patients. BMI ≥ 24 kg/m² was defined as overweight group, and BMI within the range of 18.5-23.9 kg/m² was defined as normal weight group. Preoperative stool collection of patients in both groups was used for 16S rRNA sequencing. Total RNA was extracted from 17 CRC tumor tissue samples

SUBMITTER: Huang Y 

PROVIDER: S-EPMC10854193 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature