Association between cancer and dementia risk in the UK Biobank: evidence of diagnostic bias.

ABSTRACT: Epidemiological studies have identified an inverse association between cancer and dementia. Underlying methodological biases have been postulated, yet no studies have systematically investigated the potential for each source of bias within a single dataset. We used the UK Biobank to compare estimates for the cancer-dementia association using different analytical specifications designed to sequentially address multiple sources of bias, including competing risk of death, selective survival, confounding bias, and diagnostic bias. We included 140,959 UK Biobank participants aged ≥ 55 without dementia before enrollment and with linked primary care data. We used cancer registry data to identify cancer cases prevalent before UK Biobank enrollment and incident cancer diagnosed after enrollment. We

SUBMITTER: Wang J 

PROVIDER: S-EPMC10854217 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature