Development and validation of a federated learning framework for detection of subphenotypes of multisystem inflammatory syndrome in children.

ABSTRACT:

Background

Multisystem inflammatory syndrome in children (MIS-C) is a severe post-acute sequela of SARS-CoV-2 infection. The highly diverse clinical features of MIS-C necessities characterizing its features by subphenotypes for improved recognition and treatment. However, jointly identifying subphenotypes in multi-site settings can be challenging. We propose a distributed multi-site latent class analysis (dMLCA) approach to jointly learn MIS-C subphenotypes using data across multiple institutions.

Methods

We used data from the electronic health records (EHR) systems across nine U.S. children's hospitals. Among the 3,549,894 patients, we extracted 864 patients < 21 years of age who had received a diagnosis of MIS-C during an inpatient stay or up to one day before admission. U

SUBMITTER: Jing N 

PROVIDER: S-EPMC10854314 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature