Comparative effectiveness of extended release naltrexone and sublingual buprenorphine for treatment of opioid use disorder among Medicaid patients.

ABSTRACT:

Aims

To compare the real-world effectiveness of extended release naltrexone (XR-NTX) and sublingual buprenorphine (SL-BUP) for the treatment of opioid use disorder (OUD).

Design

An observational active comparator, new user cohort study.

Setting

Medicaid claims records for patients in New Jersey and California, 2016-2019.

Participants/cases

Adult Medicaid patients aged 18-64 years who initiated XR-NTX or SL-BUP for maintenance treatment of OUD and did not use medications for OUD in the 90-days before initiation.

Comparators

New initiation with XR-NTX versus SL-BUP for the treatment of OUD.

Measurements

We examined two outcomes up to 180 days after medication initiation, 1) composite of medication discontinuation and death, and 2) composite of overd

SUBMITTER: Ross RK 

PROVIDER: S-EPMC10854342 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature