Probing a neural unreliability account of auditory sensory processing atypicalities in Rett Syndrome.

ABSTRACT:

Background

In the search for objective tools to quantify neural function in Rett Syndrome (RTT), which are crucial in the evaluation of therapeutic efficacy in clinical trials, recordings of sensory-perceptual functioning using event-related potential (ERP) approaches have emerged as potentially powerful tools. Considerable work points to highly anomalous auditory evoked potentials (AEPs) in RTT. However, an assumption of the typical signal-averaging method used to derive these measures is "stationarity" of the underlying responses - i.e. neural responses to each input are highly stereotyped. An alternate possibility is that responses to repeated stimuli are highly variable in RTT. If so, this will significantly impact the validity of assumptions about underlying neural dysfunction

SUBMITTER: Brima T 

PROVIDER: S-EPMC10854351 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature