Gut microbiota modulate CD8⁺ T cell immunity in gastric cancer through Butyrate/GPR109A/HOPX.

ABSTRACT: The gut microbiota and Short-chain fatty acids (SCFAs) can influence the progression of diseases, yet the role of these factors on gastric cancer (GC) remains uncertain. In this work, the analysis of the gut microbiota composition and SCFA content in the blood and feces of both healthy individuals and GC patients indicated that significant reductions in the abundance of intestinal bacteria involved in SCFA production were observed in GC patients compared with the controls. ABX mice transplanted with fecal microbiota from GC patients developed more tumors during the induction of GC and had lower levels of butyric acid. Supplementation of butyrate during the induction of gastric cancer along with H. pylori and N-methyl-N-nitrosourea (MNU) in WT in GPR109A^-/-mice resulted in fewer

SUBMITTER: Yu X 

PROVIDER: S-EPMC10854374 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature