Genetic variants in primary cilia-related genes associated with the prognosis of first-line chemotherapy in colorectal cancer.

ABSTRACT:

Background

Primary cilia are antenna-like organelles that conduct physical and chemical signals, which affect cell proliferation, migration, and differentiation. Some researchers have reported the correlation between primary cilia-related genes and prognosis of colorectal cancer (CRC).

Methods

The association between single nucleotide polymorphisms (SNPs) of primary cilia-related genes and outcome after the first-line chemotherapy was explored by the Cox regression model. Expression qualitative trait locus (eQTL) analysis was performed to explore the impact of SNPs on gene expression. Tumor Immune Estimation Resource and TISIDB databases were used for investigating the relevance between ODF2L and tumor infiltration immune cells and immunomodulators.

Results

We identif

SUBMITTER: Qiu L 

PROVIDER: S-EPMC10854446 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature