Macrophages Promote Subtype Conversion and Endocrine Resistance in Breast Cancer.

ABSTRACT:

Background

The progression of tumors from less aggressive subtypes to more aggressive states during metastasis poses challenges for treatment strategies. Previous studies have revealed the molecular subtype conversion between primary and metastatic tumors in breast cancer (BC). However, the subtype conversion during lymph node metastasis (LNM) and the underlying mechanism remains unclear.

Methods

We compared clinical subtypes in paired primary tumors and positive lymph nodes (PLNs) in BC patients and further validated them in the mouse model. Bioinformatics analysis and macrophage-conditioned medium treatment were performed to investigate the role of macrophages in subtype conversion.

Results

During LNM, hormone receptors (HRs) were down-regulated, while HER2 was up-r

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10854660 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature