Molecular Insights into Transcranial Direct Current Stimulation Effects: Metabolomics and Transcriptomics Analyses.

ABSTRACT:

Introduction

Transcranial direct current stimulation (tDCS) is an evolving non-invasive neurostimulation technique. Despite multiple studies, its underlying molecular mechanisms are still unclear. Several previous human studies of the effect of tDCS suggest that it generates metabolic effects. The induction of metabolic effects by tDCS could provide an explanation for how it generates its long-term beneficial clinical outcome.

Aim

Given these hints of tDCS metabolic effects, we aimed to delineate the metabolic pathways involved in its mode of action.

Methods

To accomplish this, we utilized a broad analytical approach of co-analyzing metabolomics and transcriptomic data generated from anodal tDCS in rat models. Since no metabolomic dataset was available, we performed a

SUBMITTER: Agrawal B 

PROVIDER: S-EPMC10854682 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature