Integrins in Health and Disease-Suitable Targets for Treatment?

ABSTRACT: Integrin receptors are heterodimeric surface receptors that play multiple roles regarding cell-cell communication, signaling, and migration. The four members of the β₂ integrin subfamily are composed of an alternative α (CD11a-d) subunit, which determines the specific receptor properties, and a constant β (CD18) subunit. This review aims to present insight into the multiple immunological roles of integrin receptors, with a focus on β₂ integrins that are specifically expressed by leukocytes. The pathophysiological role of β₂ integrins is confirmed by the drastic phenotype of patients suffering from leukocyte adhesion deficiencies, most often resulting in severe recurrent infections and, at the same time, a predisposition for autoimmune diseases. So far, stud

SUBMITTER: Klaus T 

PROVIDER: S-EPMC10854705 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature