Identification of a Novel Subtype-Selective α_1B-Adrenoceptor Antagonist.

ABSTRACT: α_1A-, α_1B-, and α_1D-adrenoceptors (α₁-ARs) are members of the adrenoceptor G protein-coupled receptor family that are activated by adrenaline (epinephrine) and noradrenaline. α₁-ARs are clinically targeted using antagonists that have minimal subtype selectivity, such as prazosin and tamsulosin, to treat hypertension and benign prostatic hyperplasia, respectively. Abundant expression of α₁-ARs in the heart and central nervous system (CNS) makes these receptors potential targets for the treatment of cardiovascular and CNS disorders, such as heart failure, epilepsy, and Alzheimer's disease. Our understanding of the precise physiological roles of α₁-ARs, however, and their involvement in disease has been hindered by t

SUBMITTER: Abdul-Ridha A 

PROVIDER: S-EPMC10854767 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature