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Post-Anesthesia Cognitive Dysfunction in Mice Is Associated with an Age-Related Increase in Neuronal Intracellular [Ca²⁺]-Neuroprotective Effect of Reducing Intracellular [Ca²⁺]: In Vivo and In Vitro Studies.

ABSTRACT: Background: Postoperative cognitive dysfunction (POCD) is a common disorder after general anesthesia in elderly patients, the precise mechanisms of which remain unclear. Methods: We investigated the effect of isoflurane with or without dantrolene pretreatment on intracellular calcium concentration ([Ca²⁺]_i), reactive oxygen species (ROS) production, cellular lactate dehydrogenase (LDH) leak, calpain activity, and cognitive function using the Morris water maze test of young (3 months), middle-aged (12-13 months), and aged (24-25 months) C57BL6/J mice. Results: Aged cortical and hippocampal neurons showed chronically elevated [Ca²⁺]_i compared to young neurons. Furthermore, aged hippocampal neurons exhibited

SUBMITTER: Uryash A

PROVIDER: S-EPMC10854970 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Post-Anesthesia Cognitive Dysfunction in Mice Is Associated with an Age-Related Increase in Neuronal Intracellular [Ca²⁺]-Neuroprotective Effect of Reducing Intracellular [Ca²⁺]: In Vivo and In Vitro Studies.

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Dataset Information

Post-Anesthesia Cognitive Dysfunction in Mice Is Associated with an Age-Related Increase in Neuronal Intracellular [Ca2+]-Neuroprotective Effect of Reducing Intracellular [Ca2+]: In Vivo and In Vitro Studies.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Post-Anesthesia Cognitive Dysfunction in Mice Is Associated with an Age-Related Increase in Neuronal Intracellular [Ca²⁺]-Neuroprotective Effect of Reducing Intracellular [Ca²⁺]: In Vivo and In Vitro Studies.